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vicissitude
/ˌvɪˈsɪsɪtud/
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1 · noun
a change in circumstances or fortune, often unpleasant
境遇变化；人生沉浮
Read the example to see vicissitude in context.
A sudden vicissitude of fortune forced the family to leave the city.
English pronunciation · Synthesized MP3 · Audio-factory quality review passed
命运突然逆转，迫使这个家庭离开了城市。
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Pronunciation: /ˌvɪˈsɪsɪtud/
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